Personal preference is from Poole, with Pompey a close second, the route from Calais seems to take all day, which it probably is.
There are some fantastic country roads running through the Cherbourg peninsula and down to LM. With plenty of stop offs for food and a drink. Not many Gendarmes either as it is all country roads, however this year came up a long hill and pushing on a bit as we were in tandem with a black 'vette only to find lots of Gendarmes!!! Fortunately, they were looking at the traffic coming from the opposite direction.
Another favourite route is LM to Deauville, but you only go there for a night on the tiles and just use the hotel room for somewhere to change.